Recent studies on microglia and ferroptosis in AD are also reviewed. Their role in AD iron homeostasis is emphasized. In this manuscript, we firstly discuss the role of microglia in AD and then introduce the role of microglia in the immune-inflammatory pathology of AD. Microglia dysfunction can lead to disturbances in iron metabolism and enhance iron-induced neuronal degeneration in AD, while elevated iron levels in brain areas affect microglia phenotype and function. The neurodegenerative process of AD triggers microglial activation, and the overactivation of microglia produces a large number of neuroimmune inflammatory factors. 2Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaĪlzheimer’s disease (AD), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p-tau) and neuroimmune inflammatory.1School of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.Hui-Zhi Long 1,2, Zi-Wei Zhou 1,2, Yan Cheng 1,2, Hong-Yu Luo 1,2, Feng-Jiao Li 1,2, Shuo-Guo Xu 1,2 and Li-Chen Gao 1,2*
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